Power consequences of linkage disequilibrium variation between populations
نویسندگان
چکیده
منابع مشابه
Human Genome Variation: Haplotypes, Linkage Disequilibrium, and Populations - Session Introduction
The working draft of a reference sequence of the human genome is nearing completion and is providing a basis for studies in a variety of domains. Computational challenges exist in all of these domains because of the massive amounts of data, the multiple often complex relationships among the types of relevant data, and the need to make the data accessible to researchers approaching the data from...
متن کاملLinkage disequilibrium in subdivided populations.
The linkage disequilibrium in a subdivided populaton is shown to be equal to the sum of the average linkage disequilibrium for all subpopulations and the covariance between gene frequencies of the loci concerned. Thus, in a subdivided population the linkage disequilibrium may not be 0 even if the linkage disequilibrium in each subpopulation is 0. If a population is divided into two subpopulatio...
متن کاملLinkage disequilibrium in human populations.
Whereas the human linkage map appears on limited evidence to be constant over populations, maps of linkage disequilibrium (LD) vary among populations that differ in gene history. The greatest difference is between populations of sub-Saharan origin and populations remotely derived from Africa after a major bottleneck that reduced their heterozygosity and altered their Malecot parameters, increas...
متن کاملLinkage Disequilibrium between Allozymes in Natural Populations of Lodgepole Pine.
Pairwise linkage disequilibrium values (D) were estimated for 14 allozyme loci in two natural populations of lodgepole pine (Pinus contorta ssp. latifolia). Maternal multilocus genotypes were inferred from samples of (haploid) megagametophytic seed-endosperms. Coupling/repulsion double heterozygotes were distinguished for closely linked pairs of loci. Assays of seven of the loci in seed embryos...
متن کاملvarLD: a program for quantifying variation in linkage disequilibrium patterns between populations
MOTIVATION Linkage disequilibrium (LD) differences between populations can potentially result in failure to replicate primary signals of trait association in independent genome-wide association studies (GWAS). However, such inter-population LD differences can be leveraged to narrow the search for common causal variants responsible for the association signals observed. The ability to assess and ...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2009
ISSN: 0741-0395,1098-2272
DOI: 10.1002/gepi.20366